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Product Infomation
Product NameTA-6366
CAS No.

89396-94-1

Molecular Weight

441.91

Formula

C₂₀H₂₈ClN₃O₆

SMILES

O=C([C@H](CN1C)N(C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)=O)C1=O)O.[H]Cl

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Product description

Description

                           

Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.


IC50 & Target

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ACE
In Vitro

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As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.





Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month







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