图片.png For research use only

Product Infomation
Product NamePK11000
CAS No.38275-34-2
Molecular Weight

236.63

Formula

C₆H₅ClN₂O₄S

SMILES

O=C(C1=NC(S(=O)(C)=O)=NC=C1Cl)O

Stock statusGet quote



Online consultation: s_qq.png  s_email.png



Product description

Description

PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 by covalent cysteine modification, without compromising DNA binding[1].


IC50 & Target

________________________________________________________________________________________

p53[1]


In Vitro

_________________________________________________________________________________________






Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month







Peferences:

 [1]. Bauer MR, et al. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5271-80.