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Product Infomation
Product NameBI-3812
CAS No.2166387-64-8
Molecular Weight

558.03

Formula

C₂₆H₃₂ClN₇O₅

SMILES

ClC1=CN=C(N2CCC(C(N(C)C)=O)CC2)N=C1NC3=CC(C=C(OCC(NC)=O)C(N4C)=O)=C4C(OC)=C3

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Product description

Description

BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity.


IC50 & Target

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IC50: ≤3 nM (BCL6 BTB)[1]


In Vitro

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BI-3812 is a BCL6 inhibitor, with an IC50 of ≤3 nM. BI-3812 shows an IC50 of 40 nM for the cellular BCL6[1].






Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month







Peferences:

 [1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875.